You may need to decide whether to stop breastfeeding or stop taking this medication. For seniors: The kidneys of older adults may not work as well as they used to. This can cause your body to process drugs more slowly. As a result, more of a drug stays in your body for a longer time.
This raises your risk of side effects. This dosage information is for colchicine oral tablet. All possible dosages and drug forms may not be included here. Your dosage, drug form, and how often you take the drug will depend on:. Oral tablet Colcrys. Typical dosage is 1. The kidneys of older adults may not work as well as they used to. Your doctor may start you on a lowered dose or a different dosing schedule. This can help keep levels of this drug from building up too much in your body.
However, because drugs affect each person differently, we cannot guarantee that this list includes all possible dosages. Always speak with your doctor or pharmacist about dosages that are right for you.
Colchicine oral tablet is used for long-term treatment of familial Mediterranean fever and prevention of gout flares.
It is used for short-term treatment of gout flares. If you take too much: You could have dangerous levels of the drug in your body. Symptoms of an overdose of this drug can include:. If your symptoms are severe, call or go to the nearest emergency room right away.
What to do if you miss a dose: Take your dose as soon as you remember. But if you remember just a few hours before your next scheduled dose, take only one dose. Never try to catch up by taking two doses at once. This could result in dangerous side effects.
A prescription for this medication is refillable. You should not need a new prescription for this medication to be refilled. Your doctor will write the number of refills authorized on your prescription. Your doctor may monitor your uric acid level. It can also help your doctor know if your medication is working.
Your doctor may also check for side effects. This can help make sure you stay safe while you take this drug. Your doctor may do blood tests to check your:. You may need to have certain blood tests during your treatment with colchicine. The cost of these tests depends on your insurance coverage. Many insurance companies require a prior authorization for this drug. This means your doctor may need to get approval from your insurance company before your insurance company will pay for the prescription.
Colony stimulating factors such as G-CSF have been used for the treatment of colchicine-induced leukopenia. In Europe, an experimental colchicine Fab antibody solution was used to treat patients with severe colchicine poisoning, however, this product is not currently commercially available in Europe or the United States.
Disclaimer: This website is designed to be informational and educational. Under no circumstance is this website meant to replace the expert advice of a qualified poison specialist or physician. In the event of a poison emergency, call the nearest poison center immediately by dialing or contact emergency services.
UCSF Menu. School of Pharmacy. Search form. Wed Jun 21, By Kerry A. Case presentation A 78 year old female presented to the Emergency Department ED with a history of nausea, vomiting, abdominal pain and diarrhea for three days. Were the signs and symptoms this patient experienced consistent with the different phases of colchicine toxicity? Is there an antidote available for colchicine poisoning? Epidemiology The primary use of colchicine is in the prevention and treatment of painful exacerbations of gouty arthritis.
Clinical presentation There are early and late phases of colchicine toxicity. Diagnosis A diagnosis of colchicine poisoning should be suspected in patients over thirty with a history of arthritis or gout presenting with early gastrointestinal symptoms of nausea, vomiting, and diarrhea or multisystem failure suggesting a late presentation.
Treatment Although charcoal is potentially beneficial in preventing colchicine absorption and significant enterohepatic recirculation, it is of limited utility due to initial symptoms of nausea, vomiting and hemorrhagic gastritis. Persistent nausea, abdominal pain, vomiting and diarrhea in a patient with a history of arthritis should immediately direct the clinician to consider colchicine poisoning in the differential diagnosis.
Initial gastrointestinal symptoms followed by hypotension then cardiovascular collapse and neutropenia are consistent with colchicine poisoning. No commercially available antidote is available. Aggressive supportive care is the treatment of colchicine poisoning.
Skip primary navigation. Colchicine: lower doses for greater safety. Prescriber Update. Comments There are currently no comments for this article. Make a comment:. Please login to make a comment. This article is 14 years and 2 months old.
Social sharing. In this issue Gout - Hit the target A slow death from colchicine Is carvedilol superior to metoprolol in heart failure? Lumiracoxib linked to deaths in Australia Upfront: co-enzyme Q10 supplements Dear Dave Correspondence: Low dose aspirin; IM injections 10 minute audit: Identifying your patients on colchicine. You may also like Appropriate studies have not been performed on the relationship of age to the effects of colchicine in children with gout.
Safety and efficacy have not been established. Appropriate studies performed to date have not demonstrated pediatric-specific problems that would limit the usefulness of colchicine in children with FMF 4 years of age and older.
However, safety and efficacy of colchicine have not been established in children with FMF younger than 4 years of age. Appropriate studies performed to date have not demonstrated geriatric-specific problems that would limit the usefulness of colchicine in the elderly.
However, elderly patients are more likely to have age-related kidney or liver problems which may require caution and an adjustment in the dose for patients receiving colchicine. There are no adequate studies in women for determining infant risk when using this medication during breastfeeding.
Weigh the potential benefits against the potential risks before taking this medication while breastfeeding. Although certain medicines should not be used together at all, in other cases two different medicines may be used together even if an interaction might occur.
In these cases, your doctor may want to change the dose, or other precautions may be necessary. When you are taking this medicine, it is especially important that your healthcare professional know if you are taking any of the medicines listed below.
The following interactions have been selected on the basis of their potential significance and are not necessarily all-inclusive. Using this medicine with any of the following medicines is not recommended. Your doctor may decide not to treat you with this medication or change some of the other medicines you take. Using this medicine with any of the following medicines is usually not recommended, but may be required in some cases.
If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines. Using this medicine with any of the following medicines may cause an increased risk of certain side effects, but using both drugs may be the best treatment for you. Certain medicines should not be used at or around the time of eating food or eating certain types of food since interactions may occur.
Using alcohol or tobacco with certain medicines may also cause interactions to occur. Using this medicine with any of the following is usually not recommended, but may be unavoidable in some cases. If used together, your doctor may change the dose or how often you use this medicine, or give you special instructions about the use of food, alcohol, or tobacco.
The presence of other medical problems may affect the use of this medicine. Make sure you tell your doctor if you have any other medical problems, especially:. Take this medicine exactly as directed by your doctor.
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